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Risk Factors for Myelodysplastic Syndrome (MDS)

A risk factor is something that increases your chances of getting a disease or condition. It is possible to develop MDS with or without the risk factors listed below. However, the more risk factors you have, the greater your likelihood of developing MDS. If you have a number of risk factors, ask your doctor what you can do to reduce your chance of MDS.

Factors that may increase your risk of MDS include:

  • Age—MDS is most common in people aged 65 years and older.
  • Gender—MDS most often occurs in men. However, a type of MDS associated with a missing chromosome (5q) is more common in women.
  • Genetic defects—Certain inherited diseases carry a higher risk of MDS development. Examples include:
  • Occupational or environmental exposures
    • Working in the petroleum, rubber, and agriculture industries, and exposure to certain chemical solvents, are associated with MDS.
    • Radiation from a nuclear bomb fallout increases the risk of many blood-related cancers, including MDS.
    • Radiation therapy, especially in combination with chemotherapy, is associated with with an increased risk of secondary MDS (MDS with a specific cause).
    • Lifetime exposure to radiation from medical and dental procedures may increase risk, but some tests and treatments may not be avoidable. Ask your doctor about any planned radiation exposure to determine if it is necessary.
  • Chemotherapy—Certain chemotherapy drugs used to treat cancer increase the risk of secondary MDS. This is especially true in people who have a history of Hodgkin and non-Hodgkin lymphoma, or acute lymphoblastic leukemia (ALL) during childhood.

Revision Information

  • General information about myelodysplastic syndromes. National Cancer Institute website. Available at: http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Updated August 12, 2015. Accessed June 21, 2016.

  • Myelodysplastic syndrome. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114054/Myelodysplastic-syndrome-MDS. Updated May 16, 2016. Accessed June 21, 2016.

  • Myelodysplastic syndrome. Merck Manual Professional Version website Available at: http://www.merckmanuals.com/professional/hematology-and-oncology/leukemias/myelodysplastic-syndrome. Updated October 2014. Accessed June 21, 2016.

  • Myelodysplastic syndromes. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003122-pdf.pdf. Accessed June 21, 2016.

  • Understanding myelodysplastic syndromes (MDS). MDS Foundation website. Available at: http://www.mds-foundation.org/what-is-mds. Accessed June 21, 2016.