Increased risk of AMI after adjustment for Framingham risk factors, comorbidities, substance use
WEDNESDAY, March 6 (HealthDay News) -- HIV infection is associated with an increased risk of acute myocardial infarction (AMI), even after adjustment for Framingham risk factors, according to a study published online March 4 in JAMA Internal Medicine.
Matthew S. Freiberg, M.D., from the University of Pittsburg School of Medicine, and colleagues examined whether HIV infection is associated with an increased risk of AMI, after adjustment for standard Framingham risk factors, in a cohort of 82,459 participants from the Veterans Aging Cohort Study Virtual Cohort.
During a median follow-up of 5.9 years, the researchers identified 871 AMI events. For HIV-positive individuals across three decades of age (40 to 49; 50 to 59; and 60 to 69 years) there was a consistent and significantly higher mean number of AMI events per 1,000 person-years compared with uninfected veterans (2.0 versus 1.5; 3.9 versus 2.2; and 5.0 versus 3.3, respectively). The risk of incident AMI was significantly increased for HIV-positive versus uninfected veterans, after adjustment for Framingham risk factors, comorbidities, and substance use (hazard ratio, 1.48). In time-updated analyses, the excess risk persisted among those achieving an HIV-1 RNA level of less than 500 copies/mL versus uninfected veterans (hazard ratio, 1.39).
"Veterans with HIV infection have a significantly higher risk of AMI compared with demographically and behaviorally similar uninfected veterans even after adjustment for Framingham risk factors, comorbidities, and substance use," the authors write.
One author disclosed financial ties to Merck and Gilead.
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