Principal Proposed Uses
Interactions You Should Know About
1 van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA. Brassica vegetables and cancer prevention. Epidemiology and mechanisms. Adv Exp Med Biol . 1999;472:159–68.
2 Singh SV, Srivastava SK, Choi S, et al. Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem . 2005;280:19911–24. Epub 2005 Mar 11.
3 Joseph MA, Moysich KB, Freudenheim JL, et al. Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. Nutr Cancer . 2004;50:206–13.
4 Johnston N. Sulforaphane halts breast cancer cell growth. Drug Discov Today . 2004;9:908.
5 Pham NA, Jacobberger JW, Schimmer AD, et al. The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. Mol Cancer Ther . 2004;3:1239–48.
6 Tseng E, Scott-Ramsay EA, Morris ME. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. Exp Biol Med (Maywood) . 2004;229:835–42.
7 Myzak MC, Karplus PA, Chung FL, et al. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res . 2004;64:5767–74.
8 Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA . 2002;99:7610–7615.
9 Hecht SS. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. J Nutr . 1999;129:768S–74S.
10 Verhoeven DT, Goldbohm RA, van Poppel G, et al. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact . 1997;103:79–129.
11 Talalay P, Zhang Y. Chemoprotection against cancer by isothiocyanates and glucosinolates. Biochem Soc Trans . 1996;24:806–10.
12 Nestle M. Broccoli sprouts in cancer prevention. Nutr Rev . 1998;56:127–30.
13 Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci. 1997;94:11149–51.
14 Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food Chem Toxicol . 1999;37:973–979.
15 Gamet-Payrastre L, Li P, Lumeau S, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res . 2000;60:1426–1433.
16 Solowiej E, Kasprzycka-Guttman T, Fiedor P, Rowinski W. Chemoprevention of cancerogenesis—the role of sulforaphane. Acta Pol Pharm . 2003;60:97–100.
17 Frydoonfar HR, McGrath DR, Spigelman AD. The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. ANZ J Surg . 2003;73:154–6.
18 Chiao JW, Chung FL, Kancherla R, Ahmed T, Mittelman A, Conaway CC. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int J Oncol . 2002;20:631–6.
19 Levi MS, Borne RF, Williamson JS. A review of cancer chemopreventive agents [review]. Curr Med Chem . 2001;8:1349–62.
20 Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev . 2001;10:949–54.
21 Conaway CC, Getahun SM, Liebes LL, et al. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr Cancer . 2000;38:168–78. Erratum in: Nutr Cancer . 2001;41:196.
22 Steinkellner H, Rabot S, Freywald C, et al. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutat Res . 2001;480-481:285–97.
23 Kelloff GJ, Crowell JA, Steele VE, et al. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr . 2000;130(2S Suppl):467S–471S.
24 Kunz R, Oxman AD. The unpredictability paradox: review of empirical comparisons of randomised and non-randomised clinical trials. BMJ . 1998;317:1185–90.
25 Kramer MS. Randomized trials and public health interventions: time to end the scientific double standard. ClinPerinatol . 2003;30:351–61.
26 Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114:169–70.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -