(Subacute Spongiform Encephalopathy; CJD)
- Sporadic CJD—most common type; usually affects people aged 50 years and older
- Familial CJD—an inherited form of the disease
- Iatrogenic CJD—contracted through medical procedures, such as injections of growth hormone, or receipt of corneal transplants or dura mater implants from affected donors
- Use of cadaveric growth hormone
- Cornea transplants
- Dura mater grafts
- Healthcare workers who work with brain tissues
- Blood transfusion from someone with CJD
- Memory lapses
- Difficulty concentrating
- Impaired judgment
- Difficulty with speech
- Loss of coordination
- Blurred vision
- Behavior and mood changes
- Muscle spasms
- Loss of mental and physical function
- Blood tests
- Electroencephalogram (EEG) to record the electrical activity of the brain
- Cerebrospinal fluid analysis
- Brain biopsy
- Tonsillar biopsy and brain biopsy
|MRI Scan of the Brain|
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- Prescription pain relievers
- Anticonvulsive medication for neuromuscular symptoms
Creutzfeldt-Jakob Disease Foundation, Inc. http://www.cjdfoundation.org
National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
Health Canada http://www.hc-sc.gc.ca
Public Health Agency of Canada http://www.phac-aspc.gc.ca
About CJD (Creutzfeldt-Jakob disease, classic). Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/ncidod/dvrd/cjd/index.htm. Updated November 15, 2012. Accessed June 27, 2013.
Brown K, Mastrianni JA. The prion diseases. J Geriatr Psychiatry Neurol. 2010;23(4):277-298.
CDC's diagnostic criteria for Creutzfeldt-Jakob Disease (CJD), 2010. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/ncidod/dvrd/cjd/index.htm. Updated August 26, 2010. Accessed June 27, 2013.
Creutzfeldt-Jakob disease. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated March 5, 2012. Accessed June 27, 2013.
Creutzfeldt-Jakob disease fact sheet. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/cjd/detail%5Fcjd.htm. Updated June 6, 2013. Accessed June 27, 2013.
Mastrianni JA. The genetics of prion disease. Genet Med. 2010;12(4):187-195.
Patry D, Curry B, et al. Creutzfeld-Jakob disease (CJD) after blood product transfusion from a donor with CJD. Neurology. 1998;50(6):1872-1873.
Rinne ML, McGinnis SM, et al. Clinical problem-solving. A startling decline. N Engl J Med. 2012;366(9):836-842.
- Reviewer: Rimas Lukas, MD; Brian Randall, MD
- Review Date: 06/2013 -
- Update Date: 05/11/2013 -