Lewy Body Disease
(Lewy Body Dementia; Dementia with Lewy Bodies)
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- Parkinson's disease
- Multiple system atrophy
- Alzheimer's disease
- Other disorders
- Fluctuations in alertness and attention—frequent drowsiness, lethargy, staring into space, disorganized speech, and insomnia
- Recurrent visual hallucinations
- Poor regulation of body temperature and blood pressure
- Obsessive compulsive behaviors
- Parkinsonian motor symptoms, such as rigidity or loss of spontaneous movement
- REM sleep behavior disorder
- Memory, language, and other cognitive tests
- Neuropsychological tests
- Patient and family interviews
- Imaging tests take pictures of internal bodily structures. This can be done with:
- Blood tests
- Cholinesterase inhibitors
- Glutamate blockers
Lewy Body Dementia Association http://www.lewybodydementia.org
National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
Alzheimer Society http://www.alzheimer.ca
Canadian Stroke Network http://www.canadianstrokenetwork.ca
An introduction to Lewy body dementia. Lewy Body Disease Association website. Available at: http://lbda.org/content/intro-to-lbd. Accessed August 15, 2014.
Ballard CG, Chalmers KA, Todd C, et al. Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies. Neurology. 2007;68:1726-1729.
Bouchard RW. Diagnostic criteria of dementia [review]. Can J Neurol Sci. 2007;34:(Suppl 1)S11-18.
Camicioli R, Gauthier S. Clinical trials in Parkinson's disease dementia and dementia with Lewy bodies [review]. Can J Neurol Sci. 2007;34:(Suppl 1)S109-117.
Chou KL, Borek LL, Friedman JH. The management of psychosis in movement disorder patients [review]. Expert Opin Pharmacother. 2007;8:935-943.
Dementia with Lewy bodies. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated July 18, 2014. Accessed August 15, 2014.
Dementia with Lewy bodies information page. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/dementiawithlewybodies/dementiawithlewybodies.htm. Updated May 22, 2014. Accessed August 15, 2014.
Emre M, Tsolaki M, Bonnucelli U, et al. Memantine for patients with Parkinson’s disease dementia or dementia with Lewey bodies: a randomised, double-blind, placebo controlled trial. Lancet Neurol. 2010;9(10):969-77.
Goldmann Gross R, Siderowf A, Hurtig HI. Cognitive impairment in Parkinson’s disease and dementia with Lewy bodies: a spectrum of disease. Neurosignals. 2008;16:24-34.
Jellinger KA. Formation and development of Lewy pathology: a critical update. J Neurol. 2009;256(Suppl 3):270-279.
Kemp PM, Hoffmann SA, Tossici-Bolt L, Fleming JS, Holmes C. Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies. Nucl Med Commun. 2007;28:451-456.
Meeus B, et al. The genetics of dementia with Lewy bodies: what are we missing? Arch Neurol. 2012;69(9):1113-8.
Tarawneh R, Galvin JE. Distinguishing Lewy body dementias from Alzheimer’s disease. Expert Review of Neurotherapeautics. 2007;7:1499-1516.
Weintraub D, Hurtig HI. Presentation and management of psychosis in Parkinson’s disease and dementia with Lewy bodies. Am J Psychiatry. 2007;164:1491-1498.
9/3/2014 DynaMed's Systematic Literature Surveillance. Available at: http://www.ebscohost.com/dynamed: Wippold FJ, Cornelius RS, et al. American College of Radiology (ACR) Appropriateness Criteria for dementia and movement disorders. Available at: http://www.acr.org/~/media/ACR/Documents/AppCriteria/Diagnostic/DementiaAndMovementDisorders.pdf. Updated 2014. Accessed September 3, 2014.
- Reviewer: Rimas Lukas, MD
- Review Date: 08/2014 -
- Update Date: 09/03/2014 -